Lat CLIA Kit for Rat(Rattus norvegicus) | EIAab.comLat CLIA Kit for Rat(Rattus norvegicus)

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Lat (Gene name),

Linker for activation of T-cells family member 1 (Protein name ), LAT_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Lat;

Protein name:

Linker for activation of T-cells family member 1;

Alternative:

p36-38;36 kDa phospho-tyrosine adapter protein(pp36);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK. Interacts with FCGR1A.

Function:

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Subcellular Location:

Cell membrane Single-pass type III membrane protein Present in lipid rafts.

Protein Attributes:

Sequence length:

241

Sequence:

50:

100:

150:

200:

241:

DAQPVIRAEL | ASVTSQEVED | EEEEDVDGEE | APDYENLQEL | N

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:81511

String:

O70601

UniGene:

Rn.9773

STRING:

10116.ENSRNOP00000023563

Pfam:

PF15234

Uniprot:

O70601

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ELISA Kit for Rat Linker for activation of T-cells family member 1

Cat.:

E0270h

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96T

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ELISA Kit for Rat Linker for activation of T-cells family member 1

Cat.:

E0270m

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Packing:

96T

ELISA Kit for Rat Linker for activation of T-cells family member 1

Cat.:

E0270r

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96T

CLIA Kit for Rat Linker for activation of T-cells family member 1

Cat.:

U0270m

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MSDS:

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Packing:

96T

CLIA Kit for Rat Linker for activation of T-cells family member 1

Cat.:

U0270h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Linker for activation of T-cells family member 1

Cat.:

U0270r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Linker for activation of T-cells family member 1

Cat.:

P0270Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Linker for activation of T-cells family member 1

Cat.:

P0270Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Linker for activation of T-cells family member 1

Cat.:

P0270Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Linker for activation of T-cells family member 1

Protein for Rat Linker for activation of T-cells family member 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells."
Weber J.R. , Orstavik S. , Torgersen K.M. , Danbolt N.C. , Berg S.F. , Ryan J.C. , Tasken K. , Imboden J.B. , Vaage J.T.
J. Exp. Med.187:1157-1161(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: PVG.
tissue: Natural killer cell.
2.

"Transmembrane adaptor molecules: a new category of lymphoid-cell markers."
Tedoldi S. , Paterson J.C. , Hansmann M.-L. , Natkunam Y. , Rudiger T. , Angelisova P. , Du M.Q. , Roberton H. , Roncador G. , Sanchez L. , Pozzobon M. , Masir N. , Barry R. , Pileri S. , Mason D.Y. , Marafioti T. , Horejsi V.
Blood107:213-221(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY

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